Vukojevic, J., Milavić, M., Perović, D., Ilić, S., Čilić, A. Z., Đuran, N., Štrbe, S., Zoričić, Z., Filipčić, I., Brečić, P., Seiverth, S., & Sikirić, P. (2022). Pentadecapeptide BPC 157 and the central nervous system. Neural Regeneration Research/Neural Regeneration Research , 17 (3), 482. https://doi.org/10.4103/1673-5374.320969 Sikiric, P., Gojkovic, S., Krezic, I., Smoday, I. M., Kalogjera, L., Zizek, H., Oroz, K., Vranes, H., Vukovic, V., Labidi, M., Strbe, S., Oreskovic, L. B., Sever, M., Tepes, M., Knezevic, M., Barisic, I., Blagaic, V., Vlainic, J., Dobric, I., . . . Seiwerth, S. (2023). Stable gastric pentadecapeptide BPC 157 may recover Brain–Gut axis and Gut–Brain axis function. Pharmaceuticals , 16 (5), 676. https://doi.org/10.3390/ph16050676 Seiwerth, S., Milavic, M., Vukojevic, J., Gojkovic, S., Krezic, I., Vuletic, L. B., Pavlov, K. H., Petrovic, A., Sikiric, S., Vranes, H., Prtoric, A., Zizek, H., Durasin, T., Dobric, I., Staresinic, M., Strbe, S., Knezevic, M., Sola, M., Kokot, A., . . . Sikiric, P. (2021). Stable gastric pentadecapeptide BPC 157 and wound healing. Frontiers in Pharmacology , 12 . https://doi.org/10.3389/fphar.2021.627533

Information for KPV

KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH) that inhibits NF-κB and MAPK inflammatory signaling pathways independently of melanocortin receptor activation (Dalmasso et al. 2008; Land 2012). Cellular uptake is facilitated by the H⁺-coupled oligopeptide transporter PepT1, through which KPV accumulates intracellularly and suppresses downstream pro-inflammatory cytokine expression, including TNF-α, IL-6, and IL-8 (Dalmasso et al. 2008). KPV has been investigated as a research tool in models of intestinal inflammation, including in targeted nanoparticle-based delivery systems (Xiao et al. 2017).

References

Dalmasso, G., Charrier-Hisamuddin, L., Nguyen, H. T. T., Yan, Y., Sitaraman, S., & Merlin, D. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology, 134(1), 166–178. https://doi.org/10.1053/j.gastro.2007.10.026

Land, S. C. (2012). Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: Mechanism of KPV action and a role for MC3R agonists. International Journal of Physiology, Pathophysiology and Pharmacology, 4(2), 59–73.

Xiao, B., Xu, Z., Viennois, E., Zhang, Y., Zhang, Z., Zhang, M., Han, M. K., Kang, Y., & Merlin, D. (2017). Orally targeted delivery of tripeptide KPV via hyaluronic acid-functionalized nanoparticles efficiently alleviates ulcerative colitis. Molecular Therapy, 25(7), 1628–1640. https://doi.org/10.1016/j.ymthe.2016.11.020

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GMP Certificates of Analysis

KPV<br>10.24mg<br>Batch V260409-12 001<br>4/28/2026

KPV
10.24mg
Batch V260409-12 001
4/28/2026

KPV Peptide Structure

Source: PubChem

PubChem Identifier: CID 90474670

Sequence: KPV

Molecular Formula: C18H34N4O6

Molecular Weight: 402.5 g/mol

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Product Usage

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.