Information for MOTS-c
The Mitochondrial-Derived Peptide MOTS-c promotes metabolic homeostasis and longevity, improves exercise capacity, reduces obesity, insulin resistance and other disease processes such as osteoporosis .
Research Certificates of Analysis
11.81mg
Task #42398
Batch #05072024
05/16/2024
GMP Certificates of Analysis
10.2mg
Batch #PKMOTSC10924
09/10/2024
MOTS-c Peptide Structure
Source: Wikipedia
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.64 g/mol
PubChem SID: 255386757
CAS Number: 1627580-64-6
Synonyms: Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1
What Is MOTS-c?
Prevents abnormal fat accumulations1
Improves pathways related to mitochondrial dynamics1
Enhances insulin sensitivity2
Increases metabolism of glucose3
Elevates levels of anti-inflammatory cytokines4
Research Studies
- Li, Q., Lu, H., Hu, G., Ye, Z., Zhai, D., Yan, Z., Wang, L., Xiang, A., & Lu, Z. (2019). Earlier changes in mice after D-galactose treatment were improved by mitochondria derived small peptide MOTS-c. Biochemical and Biophysical Research Communications, 513(2), 439–445. https://doi.org/10.1016/j.bbrc.2019.03.194
- Kim, S., Miller, B., Mehta, H. H., Xiao, J., Wan, J., Arpawong, T. E., Yen, K., & Cohen, P. (2019). The mitochondrial‐derived peptide MOTS‐c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiological Reports, 7(13). https://doi.org/10.14814/phy2.14171
- Zheng, Y., Wei, Z., & Wang, T. (2023). MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1120533
- Yin, X., Jing, Y., Chen, Q., Abbas, A. B., Hu, J., & Xu, H. (2020). The intraperitoneal administration of MOTS-c produces antinociceptive and anti-inflammatory effects through the activation of AMPK pathway in the mouse formalin test. European Journal of Pharmacology, 870, 172909. https://doi.org/10.1016/j.ejphar.2020.172909
Product Usage
This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
