Retatrutide (LY3437943) is a synthetic peptide engineered as a once-weekly agonist of the GIP, GLP-1, and glucagon receptors. It consists of 39 amino acids conjugated to a C20 fatty diacid moiety, with preferential potency at the GIP receptor and extended half-life enabling weekly administration (Abouelmagd et al., 2025; Jastreboff et al., 2023).
In controlled studies, retatrutide led to significant, dose-dependent reductions in body weight (up to −24.2%), BMI, and waist circumference over 48 weeks, alongside improvements in metabolic markers such as HbA1c, fasting glucose, and blood pressure. These effects are attributed to its multi-receptor mechanism enhancing energy expenditure, insulin secretion, and lipid metabolism (Abouelmagd et al., 2025).
Pharmacologically, retatrutide’s multi-agonist activity is designed to exploit synergistic pathways in metabolic regulation. GIP agonism facilitates lipid handling and insulinotropic effects, GLP-1 activity supports glucose control and satiety signaling, and glucagon receptor activation increases hepatic fat oxidation (Abouelmagd et al., 2025; Jastreboff et al., 2023; Pasqualotto et al., 2024). Together, this receptor triad promotes coordinated modulation of energy balance and glycemic control.
References
Abouelmagd, A. A., Abdelrehim, A. M., Bashir, M. N., et al. (2025). Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials. Proceedings (Baylor University Medical Center), 38(3), 291–303. https://doi.org/10.1080/08998280.2025.2456441
Pasqualotto, E., Ferreira, R. O. M., Chavez, M. P., et al. (2024). Effects of once-weekly subcutaneous retatrutide on weight and metabolic markers: A systematic review and meta analysis of randomized controlled trials. Metabolism Open, 24, 100321. https://doi.org/10.1016/j.metop.2024.100321
Jastreboff, A. M., Kaplan, L. M., Frías, J. P., et al. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. The New England Journal of Medicine, 389(6), 514– 526. https://doi.org/10.1056/NEJMoa2301972
More Information
Retatrutide Peptide Structure
2D structure image of CID 171390338 (Retatrutide):
Experience the benefits of Retatrutide 10mg, a cutting-edge triple-receptor agonist peptide designed to support weight management and metabolic health. Available now at Pekcura Labs for secure and prompt delivery.
Product Overview
Product Name: PCL Retatrutide 10mg
CAS Number: 2381089-83-2
Purity: ≥99%
Form: Lyophilized powder
Intended Use: Research purposes only
Key Benefits of Retatrutide
Study - Weight Reduction: Clinical trials have demonstrated that retatrutide can lead to significant weight loss in individuals with obesity. In a 48-week phase 2 study, participants receiving the highest dose experienced an average weight reduction of approximately 24% from baseline. [Study Reference]
Study - Enhanced Insulin Sensitivity: Retatrutide has been shown to improve insulin sensitivity and glycemic control. A study published in The Lancet reported significant reductions in HbA1c levels and fasting insulin concentrations among participants with type 2 diabetes. [Study Reference]
Study - Liver Fat Reduction: Research indicates that retatrutide may effectively reduce hepatic steatosis. In a phase 2 trial, patients with metabolic dysfunction-associated steatotic liver disease (MASLD) showed a relative liver fat reduction of over 80% after 48 weeks of treatment. [Study Reference]
Usage and Dosage Guidelines
Retatrutide is administered via subcutaneous injection. Dosage should be determined by a qualified professional based on research requirements.
Retatrutide Storage Instructions
Before Reconstitution: Store lyophilized vials at -4°F (-20°C) in a dry, cool environment.
After Reconstitution: Refrigerate at 35.6°F to 46.4°F (2°C to 8°C) and use within 14 days.
Protection: Keep away from light and moisture.
Retatrutide Safety and Handling
This product is intended for research use only. Not for human consumption. Handle with appropriate safety measures and dispose of any unused material according to institutional guidelines.
Order Now
Ready to advance your research? Buy Retatrutide 10mg today from Pekcura Labs and benefit from our commitment to quality and service.
Additional Information on Retatrutide
Retatrutide (LY3437943) is a novel triple agonist targeting the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors. This unique mechanism has been associated with significant metabolic benefits in clinical studies.
In a 48-week phase 2 trial, participants with obesity receiving retatrutide experienced a mean weight reduction of up to 24.2% from baseline. These findings suggest potential applications in weight management therapies. [Study Reference]
Additionally, retatrutide has demonstrated improvements in insulin sensitivity and glycemic control. A study published in The Lancet reported significant reductions in HbA1c levels and fasting insulin concentrations among participants with type 2 diabetes. [Study Reference]
Research also indicates that retatrutide may effectively reduce hepatic steatosis. In a phase 2 trial, patients with metabolic dysfunction-associated steatotic liver disease (MASLD) showed a relative liver fat reduction of over 80% after 48 weeks of treatment. [Study Reference]
Alternative Names for Retatrutide
Retatrutide may also be referred to by various alternative spellings and terms. For clarity and to assist in your research, please note the following variations:
These alternative terms are commonly used by researchers looking for where to purchase the peptide. When searching for information or products, consider these variations to ensure comprehensive results.
Purchasing Information
For researchers and institutions looking to acquire retatrutide, Pekcura Labs offers high-purity Retatrutide 10mg suitable for research purposes. Our product is available for purchase online with secure checkout and prompt shipping.
For inquiries regarding bulk orders, pricing, or product specifications, please contact our support team.
Product Usage
Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.
