GMP Cagrilintide
Why Choose Us?
Research-Grade
Purity
All peptides have a guaranteed purity of at least 99%.
Manufactured in
the USA
Our top-quality products are manufactured right here in the United States.
Fast
Shipping
Your products arrive at your door quickly. Plus, shipping is free for orders over $100.
Guaranteed
Freshness
Products are stored at -20° and shipped in cool shield bubble mailers.
Independently
Tested
Each batch is independently tested to ensure product purity and dosage.
Why Choose Us?
Research-Grade
Purity
All peptides have a guaranteed purity of at least 99%.
Manufactured in
the USA
Our top-quality products are manufactured right here in the United States.
Fast
Shipping
Your products arrive at your door quickly. Plus, shipping is free for orders over $100.
Guaranteed
Freshness
Products are stored at -20° and shipped in cool shield bubble mailers.
Independently
Tested
Each batch is independently tested to ensure product purity and dosage.
Order Cagrilintide
What is Cagrilintide?
Cagrilintide is a synthetic, long-acting amylin analogue engineered to improve peptide stability and extend half-life relative to native amylin. It incorporates key modifications, including 14E/17R mutations to stabilize an α-helical segment via a salt bridge, multiple proline substitutions (25P, 28P, 29P) to reduce β-sheet formation, and N-terminal C20 fatty diacid lipidation for reversible albumin binding (Kruse et al. 2021). These design features yield a pharmacokinetic profile suitable for once-weekly administration, with a reported elimination half life of 7–8 days (D’Ascanio et al. 2024).
Functionally, cagrilintide activates amylin receptors AMY1R, AMY2R, AMY3R and the calcitonin receptor (CTR), binding via a conserved “bypass” motif involving mid-segment residues (S19– P25) (Cao et al. 2025). Structural analyses show that cagrilintide mimics amylin’s receptor engagement while introducing conformational differences at select positions, such as Pro37, which enhances CTR interaction and modulates receptor dynamics (Cao et al. 2025). These receptor-specific dynamics suggest altered signaling profiles compared to other amylin-based peptides.
In vitro and preclinical studies indicate that cagrilintide retains high potency across amylin and calcitonin receptor subtypes and demonstrates additive pharmacodynamic effects when combined with GLP-1 agonists like semaglutide (D’Ascanio et al. 2024). Its dual-receptor agonism and extended activity profile position it as a promising candidate for further investigation in weight regulation models. Importantly, formulation efforts emphasize stability under physiological conditions and resistance to fibril formation—a limitation of earlier analogues such as pramlintide (Kruse et al. 2021).
D’Ascanio, A. M., Mullally, J. A., & Frishman, W. H. (2024). Cagrilintide: A long-acting amylin analog for the treatment of obesity. Cardiology in Review, 32(1), 83–90. https://doi.org/10.1097/CRD.0000000000000513
Kruse, T., Hansen, J. L., Dahl, K., Schäffer, L., Sensfuss, U., Poulsen, C., Schlein, M., Hansen, A. M. K., Jeppesen, C. B., de la Cour, C. D., Clausen, T. R., Johansson, E., Fulle, S., Skyggebjerg, R. B., & Raun, K. (2021). Development of cagrilintide, a long acting amylin analogue. Journal of Medicinal Chemistry, 64(17), 11183–11194. https://doi.org/10.1021/acs.jmedchem.1c00565
Cao, J., Belousoff, M. J., Johnson, R. M., Keov, P., Mariam, Z., Deganutti, G., Christopoulos, G., Hick, C. A., Reedtz-Runge, S., Glendorf, T., Ballarín-González, B., Raun, K., Bayly-Jones, C., Wootten, D., & Sexton, P. M. (2025). Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors. Nature Communications, 16, Article 3389. https://doi.org/10.1038/s41467-025-58680-y
FAQs
What Are Peptides?
Peptides are short chains of amino acids linked by peptide bonds. They are considered the building blocks of proteins, differing primarily in size. Proteins typically consist of one or more long polypeptide chains with more than 50 amino acids, whereas peptides usually contain between 2 and 50 amino acids. Their smaller size and specific sequences allow peptides to play various roles in biological systems and research settings.
In nature, peptides have diverse biological functions. They can act as signaling molecules such as hormones or neurotransmitters in many organisms, and they are also present in other biological compounds like antibiotics, which interact with biological systems in complex ways. One commonly cited example is insulin, a naturally occurring peptide with a well-understood structure and function in glucose regulation, studied extensively in biochemical research.
Peptides are widely used in scientific research to study protein interactions, investigate disease mechanisms at the molecular level, and explore cellular communication. Their ability to mimic or inhibit specific protein functions makes them valuable tools in laboratories exploring both fundamental biology and experimental therapeutics.
Researchers also examine peptides for their potential utility in developing advanced diagnostics, delivery systems, and laboratory models. Their specificity, modular structure, and adaptability continue to support innovative research across disciplines, including molecular biology, biochemistry, and pharmacology.
Peptides offered for sale are intended strictly for laboratory research purposes. They are not approved for human consumption, clinical use, or diagnostic purposes.
What is PekCura Labs?
Based in the US, PekCura Labs specializes in providing 99% pure peptides specifically for research purposes. Our dedication to quality, scientific integrity, and transparency is unwavering. Every peptide vial comes with QR codes for instant access to Certificate of Analysis (COAs). These reports provide a thorough breakdown of the batch test results, reinforcing your confidence in the purity and quality of the formulations you receive.
Why Choose PekCura Labs?
Top Quality: Our peptides are manufactured in the US and undergo a rigorous testing process, guaranteeing the highest quality and purity standards in the industry. We exceed industry standards by subjecting each peptide batch to two comprehensive third-party tests.
Transparency: Our unwavering commitment to transparency and quality sets us apart from competition. We prioritize delivering accurate information to our customers, eliminating any uncertainties. We provide a QR code on each vial, granting researchers instant access to batch test results and COAs for complete transparency. Every peptide vial is clearly labeled with the exact milligram amount, providing researchers with confidence in their measurements.
Excellent Customer Service: Our commitment extends beyond transactions; we strive to cultivate long-lasting relationships with our customers. Whether you need assistance, want to provide feedback, or have any inquiries, do not hesitate to contact us at Support@PekCuraLabs.com. We do everything in our power to ensure that our customers are satisfied, even after our products are delivered.
What shipping options does PekCura Labs offer?
To meet your specific needs, we offer a variety of shipping options. Additionally, PekCura Labs offers free shipping on $100+ orders.
We offer three different shipping options:
- UPS Standard Overnight*
- UPS 2Day
- Priority Mail Flat Rate (This is both an option for orders under $100 and the method we use for free shipping on orders over $100.)
* Please note: While we do offer overnight shipping, some cities do not offer UPS overnight on weekends if the order is placed on a Friday. Also, we only ship on business days. If you place your order over the weekend, you will not receive your order the next day. Orders placed on Saturday or Sunday will be shipped overnight on Monday.
What kind of packaging do we use?
We use high quality boxes and insulated mailers to confidently deliver our products to your door. At PekCura Labs, our focus is on ensuring that all peptides reach their destination in perfect condition. If your vial is not in exceptional condition when it arrives send us a message at Support@PekcuraLabs.com for a refund.
What’s the difference between GMP and research-grade peptides?
GMP (Good Manufacturing Practice) is an FDA-mandated certification. It’s the gold standard for the pharmaceutical and compounding industry, ensuring strict regulatory oversight, especially for providers and clinical settings. Yes, GMP peptides are more expensive due to these regulatory requirements, but they’re perfect for those needing to meet compliance in highly regulated environments.
Are research-grade peptides trustworthy?
Of course! Our research-based peptides are still the same high-quality peptides you’ve always known and trusted. They’re domestically sourced, with +99% purity, and they’re ideal for general research purposes. You’ll find the same molecular structure in both GMP and Research-Grade options-the difference lies in the regulatory requirements, not the quality of the product.
We introduced GMP peptides to give our customers more options, especially for those needing them for clinical or regulated use. But if you’re using peptides for research, our Research-Grade Peptides are still an excellent, cost-effective choice.
What is our privacy policy?
Your privacy is of utmost importance to us. Your data is solely utilized for order management and delivering exceptional customer service. We guarantee the confidentiality of your information, preventing any external disclosures. To prevent unauthorized access, we utilize 256 Bit SSL encryption. For a comprehensive understanding, please review our privacy policy.
